•제 목 :  Multiscale micro/nano patterns for biomedical application
•연 사 : 고원건 교수 (연세대학교 화공생명공학과)
•일 시 : 2015-10-14 , 17:00
•장 소 : D-123호

Abstract

This seminar deals with combining different types of nanomaterials with patterning process to create multiscale biopatterns. Two different applications of resultant biopatterns such as cell patterning and microfluidic-based biosensing will be introduced.

First, fabrication of micropatterned nanofiber will be described. Micropatterned scaffolds were prepared by fabricating poly(ethylene glycol) (PEG) hydrogel microstructures on electrospun nanofiber matrix, and produced as free-standing and bidirectionally-porous sheets. Since the PEG hydrogel showed non-adhesiveness toward proteins and cells, cells selectively adhered and remained viable within the nanofiber region, thereby creating cellular micropatterns. We also incorporated different functionality into resultant scaffold.

Second, we fabricated microfluidic devices composed of sets of microchannels that contain arrays of hydrogel microstructures entrapping QD-enzyme conjugates. Based on the fact that H₂O₂, a product of various oxidase-catalyzed reactions, can effectively quench the photoluminescence of QD, detection of glucose and alcohol was investigated using glucose oxidase or alcohol oxidase-conjugated QDs within microfluidic devices. We also incorporated silver nanoparticles into hydrogel micropatterns for the metal-enhanced fluorescence (MEF) biosensing

Biography

1993-1997: B.S. Department of Chemical Engineering, Yonsei University, Korea

1997-1999: M.S. Department of Chemical Engineering, Yonsei University, Korea

1999-2004: Ph.D. Department of Chemical Engineering. The Pennsylvania State University, U.S.A.

2004-2005:   Postdoctoral Scholar, School of Medicine, Department of Chemical Engineering, Stanford University, U.S.A.

2005-2009:   Assistant Professor, Department of Chemical & Biomolecular Engineering, Yonsei University, Korea

2009-2014:  Associate Professor, Department of Chemical& Biomolecular Engineering, Yonsei University, Korea

2012-2013:  Visiting Associate Professor, Department of Chemical Engineering, Stanford University, U.S.A.

2014-present: Professor, Department of Chemical& Biomolecular Engineering, Yonsei University, Korea