2021년 4월 14일(수) 17:00부터 응용바이오공학과 세미나가 진행되오니, 많은 관심과 참여 부탁드립니다.
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■ 주제 : Advanced polymeric hydrogels for in situ tissue regeneration
■ 연사 : 인천대학교 생명공학부 박경민 교수
■ 일시 : 2021년 4월 14일(수) 17:00~
■ 장소 : 코로나-19 감염대비를 위해 화상(ZOOM)으로 진행 (ID: 869 1268 5319)
The emerging trend in designing advanced hydrogels is to create a bioactive matrix stimulating the native tissues by physicochemical and biological stimuli for in situ tissue regeneration. Among various factors, it is well known that molecular oxygen (O2) plays a critical role as a signaling molecule regulating cellular activities.
In particular, hyperbaric O2 has been demonstrated to facilitate wound healing processes via transient oxidative stress. Herein, we report a hyperbaric O2-generating (HOG) hydrogel formed via calcium peroxide (CaO2)-mediated oxidative crosslinking reaction. We demonstrate that the HOG hydrogel could rapidly generate molecular O2 up to the hyperbaric levels (over 90% pO2) and release O2 from hydrogel matrices in a sustained manner (for up to 12 days). The HOG hydrogel enhances the cell proliferative activities of human dermal fibroblasts and endothelial cells in vitro. Furthermore, we found that our HOG hydrogels facilitate wound healing with enhanced tissue infiltration and improved vascular recruitment in vivo. We suggest that our HOG hydrogels have great potential as advanced O2-delivering matrices for the treatment of wound healing, vascular disorders as well as tissue regenerative medicine.
Kyung Min Park is currently an associate professor in the Department of Bioengineering and Nano-Bioengineering at Incheon National University, South Korea. Dr. Park received his Ph.D. in Molecular Science and Technology (BK21) at Ajou University in 2012. He pursued his post-doctoral training in Chemical and Biomolecular Engineering (CHEMBE) at the Johns Hopkins University from 2012 to 2015. He joined Incheon National University in 2015. His current research is focused on designing advanced polymeric biomaterials for a broad range of biomedical applications, including tissue engineering and regeneration, smart drug delivery, and engineered healthy/disease models.
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