Metal ion releasing inorganic nano-carrier for controlling cellular microenvironment

Speaker: 방석호 교수(성균관대학교)

Date & Time: 2019년 9월 11일(수), 17:00

Where: D-122호

Abstract

In this presentation, two different types of bioreducible inorganic nanoparticles releasing metal ions without cytotoxicity will be introduced. Mn ion at high concentration can be delivered to PC12 cells using AuNPs to enhance cellular neurodevelopment without causing cell death. Also, Fe ion at high concentrations can be delivered to hMSCs using AuNPs to improve angiogenic growth factors without inducing cell damage. Ion release from AuNPs was designed to be pH-sensitive so that low pH condition of the cell endosome can trigger in situ release of ions from AuNPs after cellular uptake of Mn- or Fe-incorporated AuNPs. Compared to PC12 cells treated with a high concentration of free Mn ion, PC12 cells treated with an equal concentration of MnAuNPs resulted in significantly enhanced cellular neurodevelopment with decreased apoptosis and necrosis. Treating AuFeNPs to hMSCs led enhanced therapeutic effect on skin wound healing based on improved angiogenic paracrine factor secretion.

Biography

[학력]

Unified course of the master’s and the doctor’s in School of Chemical and Biological Engineering, Seoul National University, Seoul, Republic of Korea [2003-2008]

B.S. in Chemical Engineering, Seoul National University, Seoul, Republic of Korea [2003]

[경력]

Associate Professor, School of Chemical Engineering, Sungkyunkwan University [2019. 3 – present]

Assistant Professor, School of Chemical Engineering, Sungkyunkwan University [2015. 3 – 2019. 2]

Post-doctoral fellow, School of Chemical and Biological Engineering, Seoul National University [2013 – 2015 ]

Postdoctoral Fellow, Department of Biomedical Engineering, Georgia Institute of Technology and Emory University [2011 – 2013]

 

초청자 : 융합과학부 나노융합전공 이강원 교수 (연락처 : 031-888-9145, kangwonlee@snu.ac.kr )

2019-09-10|