[융합과학부] A tool for studying mechanobiology of the blood vessel

Speaker: 김정욱 교수(서강대학교)

Date & Time: 2019년 4월 3일(수), 17:00

Where: 융대원 D-122호

Abstract

Mechanobiology is a field of science at the interface of biology and engineering and focuses on the way that physical forces and changes in cell or tissues mechanics contribute to development, physiology, and pathological condition. For example, mechanobiological study on the formation of atherosclerotic plaque in arteries revealed that disturbed blood flow near geometrically complex arteries – curved, branched, or bifurcating – contributes to increases in the permeability of endothelium and the recruitment of leukocytes, which in turn make such arterial regions to be more prone to the formation of atherosclerotic plaque. A number of tubular organs exist in our body, e.g. blood and lymphatic vessels, airways of lungs, and urethra, inside which fluids flow and exert mechanical forces, e.g. hydrostatic pressure, circumferential stress, and shear stress on luminal walls. Characteristics of the mechanical force vary upon geometrical and mechanical properties of luminal walls, which may also be varied temporally during development or pathogenesis. In light of this, a development of in vitro models of tubular organs whose geometrical and mechanical properties, and hence, the forces exerted by fluids on cells comprising luminal walls can be varied systematically would be helpful in studying mechanobiology of tubular organs. Here we present the unique method to develop the soft tubular microfluidic device that recapitulates geometrical and mechanical properties, and thus the forces exerted by fluids, of vasculatures and their pathological condition. For future studies, we aim to systematically explore the effects of the forces exerted by the blood on ECs attached on the hydrogel channel.

Biography

[학력]

Post-Doc. Massachusetts Institute of Technology, Department of Chemical Engineering, 2012
Ph.D. University of Massachusetts Amherst, Polymer Science and Engineering, 2011
M.S. University of Massachusetts Amherst, Polymer Science and Engineering, 2007
B.S. Seoul National University, School of Chemical and Biological Engineering, 2006

[경력]

Associate Professor, Chemical and Biomolecular Engineering, Sogang University, Korea [2016. 9 – present] Assistant Professor, Chemical and Biomolecular Engineering, Sogang University, Korea [2012. 9 – 2016. 9]

 

초청자 : 융합과학부 나노융합전공 송윤규 교수 (연락처 : 031-888-9133, songyk@snu.ac.kr )

2019-03-29|