[나융]Stem Cell–Recruiting Hydrogels Based on Self-Assembling Peptides for Tissue Regeneration

[나융]Stem Cell–Recruiting Hydrogels Based on Self-Assembling Peptides for Tissue Regeneration

Title: Stem Cell–Recruiting Hydrogels Based on Self-Assembling Peptides for Tissue Regeneration

Speaker: 정영미 박사(Center for Biomaterials, Korea Institute of Science and Technology)

Date & Time: 2017. 4.  19. 수요일 17:00

Where: 융대원 D-123호

 

Abstract

Stem cell based therapy in regenerative medicine may be one of the best approaches for wound healing and tissue regeneration [1]. However, although the stem cell transplantation including cell isolation and cell culture in vitro provide good prognosis, there are some limitations such as the shortage of cell source, invasiveness, high costs, as well as the risks of tumorigenesis [2]. To overcome these limitations, the technologies for recruiting endogenous stem cells to the injured site can be another promising approach, which mimic in situ tissue regeneration by wound healing process of our body. It was reported that substance P (SP), as another candidate enhancing recruitment of host stem cells, is an injury-inducible factor that acts early in the wound healing process to induce CD29+ stromal-like cell mobilization and so, it can used for tissue regeneration [1]. Recently, we designed the bioactive self-assembling peptide hydrogels which could recruit mesenchymal stem cells by coupling SAP to SP and applied to the animal defect models. The mixture of SAP and SP coupled SAP was maintained their nanofibrous structure and assembled into a 3D scaffold at physiological conditions. We confirmed the inducible ability for stem cells of this SP coupled SAP by in vitro cell migration assay and in vivo real-time cell tracking assay (Figure 1). Consequently, bioactive peptides could recruit MSCs successfully, prevent cell apoptosis, and promote tissue regeneration that led to full recovery of defects. So, we expect that stem cell recruiting hydrogels based on self-assembling peptides could be one of the most powerful tools for tissue regeneration without cells transplantation by recruiting endogenous stem cells

Biography

학력

Ph.D., Dept. of Biomedical Engineering, Seoul National University (2008)
M.S., Dept. of Biomedical Engineering, Seoul National University (2003)
B.S., Dept. of Chemical Engineering, Seoul National University (2001)

경력

2017-Present, Principle Research Scientist, Korea Institute of Science and Technology
2011-Present, Associate Professor, BME, University of Science and Technology
2010-2017, Senior Research Scientist, Korea Institute of Science and Technology
2012-2013, Visiting Scholar, Department of Biomedical Engineering, Duke University

 

초청자 : 융합과학부 나노융합전공 박원철 교수 (연락처 : 031-888-9141, parkat9@snu.ac.kr)

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