Hydrogel-Incorporated Nanomaterials for Biomedical Application

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작성자 관리자 댓글 0건 조회 137회 작성일 20-06-01 11:11

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■ 세미나(ZOOM 화상회의) : https://snu-ac-kr.zoom.us/j/95012821970


Abstract


This seminar deals with combining different types of nanomaterials with patterning process to create multiscale biopatterns.  Two different applications of resultant biopatterns such as tissue engineering and biosensing will be introduced.


First, fabrication of micropatterned nanofiber will be described. Micropatterned scaffolds were prepared by fabricating poly(ethylene glycol) (PEG) hydrogel microstructures on electrospun nanofiber matrix, and produced as free-standing and bidirectionally-porous sheets. Since the PEG hydrogel showed non-adhesiveness toward proteins and cells, cells selectively adhered and remained viable within the nanofiber region, thereby creating cellular micropatterns. Different proteins and could be immobilized onto resultant micropatterned nanofiber scaffold, carrying out cell patterning, metabolite detection, and growth factor delivery.


Second, we developed a novel silver-based metal-enhanced fluorescence (MEF) biosensing platform that consisted of poly(ethylene glycol)(PEG) hydrogel microstructures entrapping silica-coated AgNPs (Ag@SiO2). AgNPs were coated with different thickness of silica to optimize the MEF effects.  As a model system, the fluorescence detection of glucose or paraoxon were introduced.  For the detection of glucose, hydrogel microstructures entrapping glucose oxidase (GOX), peroxidase (POD) and Ag@SiO2 were prepared by a simple photopatterning process. On the other hands, detection of paraoxon was achieved by decorating QDs on the surface of Ag@SiO2. In both cases, we took advantage of the MEF from Ag@SiO2 within the hydrogel microstructures to improve the performance of the fluorescence detection device.





초청자 : 융합과학부 나노융합전공 이강원 교수 (연락처: 031-888-9145) 

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